Description

Hs-Peg4-Tbu CAS NO 564476-33-1 is a specialized polyethylene glycol (PEG)-based linker compound featuring a tert-butyl (tBu) protecting group. This chemical serves as a critical building block in the synthesis of complex molecules, offering controlled conjugation and enhanced solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing advanced drug delivery systems, antibody-drug conjugates (ADCs), and diagnostic probes.

Application

• Bioconjugation Linker: A key reagent for attaching drugs, dyes, or other functional molecules to proteins, peptides, or antibodies.
• ADC (Antibody-Drug Conjugate) Development: Used in the construction of linker-payload complexes for targeted cancer therapies.
• Proteolysis-Targeting Chimeras (PROTACs): Serves as a flexible spacer to connect the E3 ligase ligand and the target protein ligand.
• Polymer Chemistry: Acts as a functional monomer or initiator for synthesizing PEGylated polymers with tailored properties.
• Diagnostic Reagents: Employed in the preparation of contrast agents or fluorescent probes for imaging applications.
• Material Science: Used to modify surface properties and create hydrophilic coatings or hydrogels.

Basic Information

Product Name	Hs-Peg4-Tbu
CAS No.	564476-33-1
Molecular Formula	C21H41NO8
Molecular Weight	435.56 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester; tert-Butyl (17-((tert-butoxycarbonyl)amino)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecan-1-yl)carbamate (Long-form IUPAC); HS-PEG4-t-butyl ester; Boc-NH-PEG4-tBu; Amino-PEG4-t-butyl ester; N-Boc-N'-t-butyl-PEG4; PEG4 tert-butyl ester linker
EINECS	Contact for details

Quality Control

Every batch of Hs-Peg4-Tbu is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and moisture absorption. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.