Description

Bromo-Peg4-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal bromo group and a protected carboxylic acid. This compound is a crucial bifunctional linker and building block in advanced organic synthesis and bioconjugation chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for creating targeted drug delivery systems, developing novel bioconjugates, and synthesizing functional polymers.

Application

• Pharmaceutical Linker Chemistry: Serves as a versatile spacer and reactive handle for conjugating drug molecules, targeting ligands, or imaging agents.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Acts as a starting material for synthesizing heterobifunctional PEG crosslinkers (e.g., NHS-PEG-Br, Maleimide-PEG-Br) for protein and peptide modification.
• Polymer Synthesis: Functions as an initiator or monomer in controlled radical polymerization (e.g., ATRP) to create well-defined, functionalized polymers and copolymers.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, or other material surfaces with reactive bromo groups for further chemical grafting.
• Prodrug Synthesis: Utilized to attach promoieties via the ester group, which can be cleaved under specific physiological conditions to release the active drug.

Basic Information

Product Name	Bromo-Peg4-T-Butyl Ester
CAS No.	564476-32-0
Molecular Formula	C17H33BrO7
Molecular Weight	429.35 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-bromo-3,6,9,12-tetraoxa-2-azatetradec-1-yl-1,1-dimethylethyl ester; 1-Bromo-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; Bromo-PEG4-t-butyl ester; t-Butyl 15-bromo-3,6,9,12-tetraoxapentadecanoate; Br-PEG4-COOtBu; tert-Butyl bromo(tetraethylene glycol)acetate; Bromo-PEG4-acid t-butyl ester; 15-Bromo-3,6,9,12-tetraoxapentadecanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Bromo-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. The product is moisture-sensitive and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.