Description

4-(2-(1H-Benzo[D]Imidazol-2-Ylthio) Ethyl) Piperazine-1-Carbaldehyde is a sophisticated heterocyclic organic compound featuring a benzimidazole core linked to a piperazine carbaldehyde moiety via a thioether bridge. This unique molecular architecture makes it a valuable pharmaceutical intermediate and key building block in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing libraries of compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The benzimidazole-piperazine structure is relevant in the design of inhibitors for enzymes like HCV NS5A and other viral proteases.
• Kinase Inhibitor Synthesis: Used as a building block in the development of kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(2-(1H-Benzo[D]Imidazol-2-Ylthio) Ethyl) Piperazine-1-Carbaldehyde
CAS No.	561023-88-9
Molecular Formula	C15H18N4OS
Molecular Weight	302.39 g/mol
Synonyms	4-[2-(1H-Benzimidazol-2-ylsulfanyl)ethyl]piperazine-1-carbaldehyde; 1-Piperazinecarboxaldehyde, 4-[2-(2-benzimidazolylthio)ethyl]-; 4-(2-(1H-Benzoimidazol-2-ylthio)ethyl)piperazine-1-carboxaldehyde; 4-[2-(1H-1,3-Benzodiazol-2-ylsulfanyl)ethyl]piperazine-1-carbaldehyde; Benzimidazole-piperazine carbaldehyde derivative; CAS 561023-88-9
EINECS	Contact for details

Quality Control

Our 4-(2-(1H-Benzo[D]Imidazol-2-Ylthio) Ethyl) Piperazine-1-Carbaldehyde is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical intermediate supply, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.