Description

Dapsone-D8 (Major) is a high-purity, deuterium-labeled analog of the pharmaceutical compound dapsone, specifically designed for advanced research and analytical applications. This stable isotope-labeled standard is critical for ensuring accuracy and reliability in quantitative mass spectrometry, where it serves as an internal reference to correct for variations in sample preparation and instrument response. It is an essential tool for scientists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors who require precise measurement of dapsone and its metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for bioanalytical method development and validation.
• Pharmacokinetic and Metabolite Studies: Enables accurate tracking of dapsone absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Used in vitro and in vivo studies to investigate metabolic pathways and enzyme kinetics without interference from endogenous compounds.
• Forensic and Clinical Toxicology: Supports the precise quantification of dapsone in patient samples for therapeutic drug monitoring or forensic analysis.
• Quality Control in Pharmaceutical Manufacturing: Assays the active pharmaceutical ingredient (API) and ensures batch-to-batch consistency during production.
• Environmental and Food Safety Testing: Potential use in trace analysis for monitoring dapsone residues in environmental samples or food products.

Basic Information

Product Name	Dapsone-D8 (Major)
CAS No.	557794-38-4
Molecular Formula	C12H4D8N2O2S
Molecular Weight	252.35 g/mol
Synonyms	4,4'-Sulfonylbis[2,3,5,6-tetradeuterioaniline]; Dapsone-d8; [2H8]-Dapsone; Deuterated Dapsone; 4-Amino-2,3,5,6-tetradeuterio-N-(4-amino-2,3,5,6-tetradeuteriophenyl)benzenesulfonamide; Bis(4-amino-2,3,5,6-tetradeuteriophenyl) sulfone; DADPS-d8
EINECS	Contact for details

Quality Control

Our Dapsone-D8 (Major) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic tests, including NMR for deuterium incorporation and HPLC for chemical purity. We adhere to relevant industry guidelines for stable isotope-labeled compounds to guarantee reliable performance and traceability in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.