Description

4-Methoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is a high-value organosilicon building block and triflate ester, primarily used as a key intermediate in advanced organic synthesis. Its core value lies in enabling efficient and selective coupling reactions, particularly in the construction of complex pharmaceutical and agrochemical molecules. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for coupling reactions like Suzuki-Miyaura and Negishi cross-couplings.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where its triflate group acts as an excellent leaving group for C-C bond formation.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials requiring precise molecular architecture.
• Cross-Coupling Reactions: Specifically valuable in palladium-catalyzed reactions to introduce the 4-methoxy-2-(trimethylsilyl)phenyl moiety into target molecules.
• Protecting Group Chemistry: The trimethylsilyl group can serve as a protective group for phenols in multi-step synthetic sequences.

Basic Information

Product Name	4-Methoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	556812-41-0
Molecular Formula	C11H15F3O4SSi
Molecular Weight	328.38 g/mol
Synonyms	2-Methoxy-5-(trimethylsilyl)phenyl triflate; 4-Methoxy-2-(trimethylsilyl)phenyl triflate; 1-Methoxy-4-(trimethylsilyl)-2-(trifluoromethanesulfonyloxy)benzene; (4-Methoxy-2-(trimethylsilyl)phenyl) trifluoromethanesulfonate; Trifluoromethanesulfonic acid 4-methoxy-2-(trimethylsilyl)phenyl ester; 4-Methoxy-2-TMS-phenyl triflate
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.