Description

3-Thiophenecarboxylic Acid, Tetrahydro-3-Hydroxy-, (3S)- (9Ci) is a high-value, chiral intermediate characterized by its tetrahydrothiophene core bearing both carboxylic acid and hydroxyl functional groups. This compound matters for its role as a sophisticated building block in the synthesis of complex molecules, particularly in the pharmaceutical sector where stereochemical purity is critical. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and advanced material industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of new drug candidates, especially those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where its unique heterocyclic structure can contribute to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing the efficiency and selectivity of chemical transformations.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to the electron-rich thiophene moiety.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3-Thiophenecarboxylic Acid, Tetrahydro-3-Hydroxy-, (3S)- (9Ci)
CAS No.	552888-23-0
Molecular Formula	C6H8O3S
Molecular Weight	160.19 g/mol
Synonyms	(3S)-Tetrahydro-3-hydroxy-3-thiophenecarboxylic acid; (3S)-3-Hydroxytetrahydrothiophene-3-carboxylic acid; Tetrahydro-3-hydroxy-3-thiophenecarboxylic acid, (3S)-; (S)-3-Hydroxytetrahydrothiophene-3-carboxylic acid; 3-Thiophenecarboxylic acid, tetrahydro-3-hydroxy-, (3S)-; 552888-23-0; (3S)-3-Hydroxy-tetrahydro-thiophene-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Thiophenecarboxylic Acid, Tetrahydro-3-Hydroxy-, (3S)- (9Ci) is produced under a strict quality management system. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation of quality, especially after the original container has been opened. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.