Description

4-Fluoro-2,3-Dihydro-1H-Indole Hydrochloride is a high-purity, versatile pharmaceutical intermediate and building block of significant importance in modern organic synthesis. Its value lies in its role as a key precursor for the development of novel bioactive molecules, particularly in medicinal chemistry. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Organic Synthesis: Serves as a versatile precursor for constructing complex indole-based heterocycles, which are common scaffolds in medicinal chemistry.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation and mechanism-of-action studies.
• Material Science: Potential use as a monomer or functional component in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Product Name	4-Fluoro-2,3-Dihydro-1H-Indole Hydrochloride
CAS No.	552866-98-5
Molecular Formula	C8H9FN2·HCl
Molecular Weight	188.62 g/mol (Free base: 152.17 g/mol)
Synonyms	4-Fluoro-2,3-dihydro-1H-indole HCl; 4-Fluoroindoline Hydrochloride; 4-Fluoro-2,3-dihydro-1H-indole, hydrochloride; 1H-Indole, 4-fluoro-2,3-dihydro-, hydrochloride; 4-Fluoroindoline HCl; 4-F-Indoline HCl; 4-Fluoro-2,3-dihydroindole Hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2,3-Dihydro-1H-Indole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.