Description

5-Bromo-3,3-difluoro-1,3-dihydro-indol-2-one is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and fluorinated oxindole structure. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies due to its modifiable bromo and difluoro substituents.
• Agrochemical Development: Serves as a building block for creating new active ingredients in crop protection products.
• Organic Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex heterocyclic systems into target molecules.
• Chemical Biology: Utilized in the design and synthesis of chemical probes for studying biological pathways and protein function.

Basic Information

Product Name	5-Bromo-3,3-difluoro-1,3-dihydro-indol-2-one
CAS No.	552332-19-1
Molecular Formula	C8H4BrF2NO
Molecular Weight	248.03 g/mol
Synonyms	5-Bromo-3,3-difluoroindolin-2-one; 5-Bromo-3,3-difluoro-2-indolinone; 2H-Indol-2-one, 5-bromo-3,3-difluoro-1,3-dihydro-; 5-Bromo-3,3-difluorooxindole; 552332-19-1; 5-Bromo-3,3-difluoro-1,3-dihydro-2H-indol-2-one
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-3,3-difluoro-1,3-dihydro-indol-2-one adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere if long-term storage is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.