Description

1-Boc-5-Bromo-Indazole is a high-purity, protected heterocyclic building block of significant importance in modern organic synthesis. This compound is specifically engineered to facilitate the efficient construction of complex molecular architectures, offering a strategic balance of reactivity and stability. It is an essential intermediate for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular modification is critical.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the indazole scaffold's bioactivity.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes, inhibitors, and tool compounds for studying biological systems.
• Material Science: Employed in the synthesis of specialty polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings for carbon-carbon and carbon-heteroatom bond formation.
• Library Synthesis: A valuable building block for combinatorial and parallel synthesis in medicinal chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	1-Boc-5-Bromo-Indazole
CAS No.	552331-49-4
Molecular Formula	C₁₂H₁₃BrN₂O₂
Molecular Weight	297.15 g/mol
Synonyms	5-Bromo-1-[(tert-butoxy)carbonyl]-1H-indazole; 1H-Indazole, 5-bromo-1-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 5-bromo-1H-indazole-1-carboxylate; 1-Boc-5-bromoindazole; 5-Bromo-1-Boc-indazole; Boc-5-Br-indazole; 5-Bromo-1-(tert-butoxycarbonyl)indazole; 1-(tert-Butoxycarbonyl)-5-bromoindazole
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Bromo-Indazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.