Description

4-Mercapto-8-(Trifluoromethyl)Quinoline is a high-purity, multifunctional heterocyclic building block characterized by its unique combination of a quinoline core, a reactive thiol group, and a trifluoromethyl substituent. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where the introduction of fluorine atoms and sulfur-containing moieties is critical for modulating biological activity and physicochemical properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, infectious diseases, and oncology, where the trifluoromethyl group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the thiol group for conjugation and the fluorine atoms for improved efficacy and environmental profile.
• Ligand and Catalyst Development: Acts as a versatile ligand or precursor for metal-organic complexes used in catalysis, due to the electron-donating and coordinating properties of the mercapto group.
• Material Science Research: Employed in the creation of advanced organic electronic materials, such as OLEDs or conductive polymers, where the quinoline structure contributes to electron transport properties.
• Chemical Biology Probes: Utilized as a building block for fluorescent probes or affinity tags, where the thiol allows for specific bioconjugation to proteins or other biomolecules.

Basic Information

Product Name	4-Mercapto-8-(Trifluoromethyl)Quinoline
CAS No.	550346-16-2
Molecular Formula	C10H6F3NS
Molecular Weight	229.22 g/mol
Synonyms	8-(Trifluoromethyl)quinoline-4-thiol; 4-Quinolinethiol, 8-(trifluoromethyl)-; 4-Mercapto-8-trifluoromethylquinoline; 8-Trifluoromethyl-4-mercaptoquinoline; 4-Thiol-8-trifluoromethylquinoline; 4-SH-8-CF3-Quinoline; 8-CF3-Quinoline-4-thiol
EINECS	Contact for details

Quality Control

Our 4-Mercapto-8-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements of research and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.