Description

(1R*,2'R*)-1-(2'-Hydroxy-2'-Phenylethyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline is a sophisticated chiral tetrahydroisoquinoline derivative, a key structural motif in medicinal chemistry. This compound matters as a critical pharmaceutical intermediate and a versatile building block for the synthesis of complex bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, alkaloid-based therapeutics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates targeting neurological receptors.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in alkaloid and isoquinoline-based drug discovery.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical products.
• Biochemical Tool Compound: Used in pharmacological research to study enzyme inhibition or receptor binding mechanisms.
• Organic Synthesis Building Block: For constructing complex natural product analogs and heterocyclic compounds.

Basic Information

Item	Details
Product Name	(1R*,2'R*)-1-(2'-Hydroxy-2'-Phenylethyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline
CAS No.	548443-20-5
Molecular Formula	C19H23NO3
Molecular Weight	313.39 g/mol
Synonyms	6,7-Dimethoxy-1-[(1R,2R)-2-hydroxy-2-phenylethyl]-1,2,3,4-tetrahydroisoquinoline; (1R,2R)-1-(2-Hydroxy-2-phenylethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; rel-(1R,2R)-1-(2-Hydroxy-2-phenylethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; Tetrahydroisoquinoline derivative 548443-20-5; Chiral tetrahydroisoquinoline alcohol; THIQ derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request. We adhere to a cGMP-compliant quality management system suitable for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.