Description

(R)-2-((R)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-2-Phenyl-Ethanol is a high-purity chiral intermediate of significant importance in modern asymmetric synthesis. Its defined stereochemistry makes it a critical building block for the development of novel, single-enantiomer active pharmaceutical ingredients (APIs). This compound is essential for research and manufacturing organizations in the pharmaceutical and fine chemical sectors seeking to develop or produce optically pure therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex APIs, particularly for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical reactions to control the formation of specific enantiomers.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for commercial pharmaceutical manufacturing.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(R)-2-((R)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-2-Phenyl-Ethanol
CAS No.	548443-18-1
Molecular Formula	C19H23NO3
Molecular Weight	313.39 g/mol
Synonyms	(1R)-2-[(6R)-6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-1-yl]-1-phenylethanol; (R,R)-6,7-Dimethoxy-1-(2-hydroxy-2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline; (R,R)-THIQ Ethanol Derivative; (R)-2-((R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-2-phenylethanol; (R,R)-DMTIQ Ethanol; Chiral Tetrahydroisoquinoline Ethanol
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high optical purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry to confirm identity, enantiomeric excess (ee), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.