Description

2-(2-Cyano-Acetylamino)-4-p-Tolyl-Thiophene-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting specific enzymatic pathways.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex thiophene-based heterocycles and studying structure-activity relationships (SAR).
• Agrochemical Development: Serves as a precursor in the research and development of new-generation crop protection agents and herbicides.
• Material Science: Investigated for potential use in the development of organic semiconductors and specialty polymers due to its conjugated system.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2-(2-Cyano-Acetylamino)-4-p-Tolyl-Thiophene-3-Carboxylic Acid Ethyl Ester
CAS No.	546071-64-1
Molecular Formula	C17H16N2O3S
Molecular Weight	328.38 g/mol
Synonyms	Ethyl 2-[(2-cyanoacetyl)amino]-4-(4-methylphenyl)thiophene-3-carboxylate; 2-[(2-Cyanoacetyl)amino]-4-(4-methylphenyl)-3-thiophenecarboxylic Acid Ethyl Ester; 4-p-Tolyl-2-[(cyanoacetyl)amino]thiophene-3-carboxylic Acid Ethyl Ester; 2-Cyanoacetamido-4-p-tolylthiophene-3-carboxylic Acid Ethyl Ester; 546071-64-1; CAATCE; Thiophene-3-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 2-(2-Cyano-Acetylamino)-4-p-Tolyl-Thiophene-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications from research scale to cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.