Description

cis-4-Oxo-Octahydro-Isoindole-2-Carboxylic Acid tert-Butyl Ester is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex, biologically active molecules with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Chemistry: Used to incorporate constrained proline-like structures into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing novel, stereochemically defined pesticides and herbicides.
• Asymmetric Catalysis Ligand Precursor: Provides a scaffold for the development of novel chiral ligands and organocatalysts.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Custom Synthesis Projects: Employed in the contract manufacturing of specialty fine chemicals and advanced intermediates for clients worldwide.

Basic Information

Item	Details
Product Name	cis-4-Oxo-Octahydro-Isoindole-2-Carboxylic Acid tert-Butyl Ester
CAS No.	543910-82-3
Molecular Formula	C₁₃H₂₁NO₃
Molecular Weight	239.31 g/mol
Synonyms	(3aS,7aR)-Hexahydro-1H-isoindole-1,3(2H)-dione-2-carboxylic acid tert-butyl ester; cis-4-Oxo-octahydroisoindole-2-carboxylic acid tert-butyl ester; tert-Butyl cis-4-oxooctahydro-1H-isoindole-2-carboxylate; BOC-protected cis-4-oxo-octahydroisoindole-2-carboxylic acid; (3aS,7aR)-2-(tert-Butoxycarbonyl)octahydro-1H-isoindole-1,3(2H)-dione
EINECS	Contact for details

Quality Control

Every batch of cis-4-Oxo-Octahydro-Isoindole-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical R&D. Our products are characterized by multiple orthogonal techniques to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), chiral purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (cis-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.