Description

4,4'-Dimethoxy-3''-Methyltrityl Alcohol is a specialized trityl-protected alcohol derivative, a key intermediate in modern organic synthesis. Its value lies in its role as a versatile protecting group reagent, offering selective protection for hydroxyl functionalities in complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the synthesis of oligonucleotides, peptides, and other sensitive bioactive molecules where precise chemical control is paramount.

Application

• Oligonucleotide Synthesis: Primarily used as a key protecting group reagent for the 5'-hydroxyl group in phosphoramidite-based solid-phase DNA/RNA synthesis.
• Peptide Chemistry: Employed for the selective protection of serine, threonine, or tyrosine side chains during complex peptide assembly.
• Carbohydrate Chemistry: Useful for the temporary protection of specific hydroxyl groups in the synthesis of complex sugars and glycoconjugates.
• Pharmaceutical Intermediates: Serves as a critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Chemical Research & Development: A valuable tool for synthetic chemists in academia and industry for developing new methodologies and constructing molecular libraries.
• Material Science: Potential applications in the synthesis of specialty polymers and advanced materials requiring controlled functionalization.

Basic Information

Product Name	4,4'-Dimethoxy-3''-Methyltrityl Alcohol
CAS No.	541540-97-0
Molecular Formula	C22H22O3
Molecular Weight	334.41 g/mol
Synonyms	3''-Methyl-4,4''-dimethoxytrityl alcohol; DMT-MMT-OH; 4,4'-Dimethoxy-3'-methyltrityl alcohol; (4,4'-Dimethoxy-3-methylphenyl)diphenylmethanol; MMTr-OH; 3-Methyl-4,4'-dimethoxytrityl alcohol; 1-[Bis(4-methoxyphenyl)(3-methylphenyl)methyl]ethanol (tautomer)
EINECS	Contact for details

Quality Control

Our 4,4'-Dimethoxy-3''-Methyltrityl Alcohol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.