Description

(-)-n-Bisdesmethyltramadol is a high-purity pharmaceutical intermediate and analytical reference standard. This compound is of significant value for research and development in medicinal chemistry, particularly in the study of analgesic pathways and metabolite profiling. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on neuropharmacology and drug metabolism.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel analgesic compounds and for studying structure-activity relationships.
• Analytical Reference Standard: Used for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of tramadol and its metabolites in pharmaceutical formulations and biological matrices.
• Metabolite Research: Serves as a key reference material for the identification and characterization of tramadol metabolites in pharmacokinetic and toxicological studies.
• Biochemical Research: Employed in in-vitro studies to investigate ligand-receptor interactions and the mechanisms of action related to opioid and monoamine systems.
• Quality Control: Acts as a certified standard for ensuring the purity and consistency of active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	(-)-n-Bisdesmethyltramadol
CAS No.	541505-94-6
Molecular Formula	C15H23NO2
Molecular Weight	249.35 g/mol
Synonyms	(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; O-Desmethyltramadol Metabolite; Tramadol Metabolite M2; (-)-O-Desmethyltramadol; (1R,2R)-Tramadol Metabolite O-desmethyl; N/A
EINECS	Contact for details

Quality Control

Our (-)-n-Bisdesmethyltramadol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.