Description

6-Azabicyclo[3.1.0]Hexane-2,3-Diol, 4-(Hydroxymethyl)-, (1R,2R,3R,4R,5R)- (9Ci) is a high-purity, stereochemically defined bicyclic amino alcohol building block of significant interest in advanced organic synthesis. Its unique, rigid scaffold containing multiple functional groups makes it a valuable chiral intermediate for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical R&D and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), especially nucleoside analogs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel nucleoside and nucleotide analogs for antiviral or anticancer therapies.
• Advanced Organic Synthesis: Serves as a constrained, multifunctional building block for constructing complex, polycyclic molecular frameworks in medicinal chemistry.
• Ligand and Catalyst Development: Used in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Bioconjugation and Probe Synthesis: The hydroxyl and amine functionalities allow for derivatization to create chemical probes for biochemical research.
• Peptidomimetics: The bicyclic structure can mimic peptide turns, making it useful in the design of peptide-like drug candidates.
• Academic and Industrial R&D: Employed in research laboratories for method development and exploring new chemical space in drug discovery programs.

Basic Information

Product Name	6-Azabicyclo[3.1.0]Hexane-2,3-Diol, 4-(Hydroxymethyl)-, (1R,2R,3R,4R,5R)- (9Ci)
CAS No.	540776-09-8
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(1R,2R,3R,4R,5R)-4-(Hydroxymethyl)-6-azabicyclo[3.1.0]hexane-2,3-diol; (1R,2R,3R,4R,5R)-4-(Hydroxymethyl)-6-azabicyclo[3.1.0]hexane-2,3-diol (9CI); 6-Azabicyclo[3.1.0]hexane-2,3-diol, 4-(hydroxymethyl)-, (1R,2R,3R,4R,5R)-; 540776-09-8; (1R,2R,3R,4R,5R)-4-(Hydroxymethyl)-6-azabicyclo[3.1.0]hexane-2,3-diol; Bicyclic amino alcohol derivative
EINECS	Contact for details

Quality Control

Our 6-Azabicyclo[3.1.0]Hexane-2,3-Diol, 4-(Hydroxymethyl)-, (1R,2R,3R,4R,5R)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.