Description

4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine atoms, which can dramatically alter the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and oncology research, where the difluoro motif can enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging fluorine's ability to improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for specialty chemicals, liquid crystals, and advanced polymers requiring specific fluorinated architectures.
• Medicinal Chemistry Scaffold: The tetrahydroisoquinoline core is a privileged structure in drug discovery, used to explore new chemical space and structure-activity relationships (SAR).
• Fluorine Chemistry Research: An essential reagent for academic and industrial laboratories studying novel fluorination reactions and the effects of fluorine substitution.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial quantities for client projects.

Basic Information

Product Name	4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	537033-81-1
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	4,4-Difluoro-1,2,3,4-tetrahydroisoquinoline; 4,4-Difluoro-1,2,3,4-tetrahydro-isoquinoline; 1,2,3,4-Tetrahydro-4,4-difluoro-isoquinoline; 4,4-Difluorotetrahydroisoquinoline; 4,4-Difluoro-3,4-dihydro-1H-isoquinoline; 4,4-Difluoro-1,2,3,4-tetrahydroisoquinoline; 4,4-Difluoro-1,2,3,4-tetrahydroisoquinoline (CAS 537033-81-1)
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data with each shipment to support your R&D and scale-up activities. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are issued for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.