Description

6-Chloro-1-(4-Methylphenyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydro-β-carboline class of heterocyclic compounds. This compound matters for its critical role as a sophisticated building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this high-value intermediate for developing new therapeutic agents and scaling up production processes.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially within the neuropharmacology and psychopharmacology domains.
• Research & Development: Used in academic and industrial laboratories for medicinal chemistry research, structure-activity relationship (SAR) studies, and hit-to-lead optimization.
• API Synthesis: Integral building block for constructing complex molecular architectures found in potential therapeutics for neurological conditions.
• Biochemical Research: Employed as a reference standard or probe compound in biochemical assays to study receptor binding and enzyme inhibition.
• Fine Chemical Production: Utilized in multi-step organic synthesis for the manufacture of specialized, high-value chemicals.

Basic Information

Item	Details
Product Name	6-Chloro-1-(4-Methylphenyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole
CAS No.	529476-80-0
Molecular Formula	C18H17ClN2
Molecular Weight	296.80 g/mol
Synonyms	6-Chloro-1-p-tolyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 1-(4-Methylphenyl)-6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 6-Chloro-1-(4-methylphenyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole; Tetrahydro-β-carboline derivative; 6-Cl-1-p-Tolyl-THBC; 529476-80-0; 6-Chloro-1-(4-methylphenyl)-2,3,4,9-tetrahydro-β-carboline
EINECS	Contact for details

Quality Control

Our 6-Chloro-1-(4-Methylphenyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical development and production stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.