Description

1-(2-Chloro-4-Fluorobenzyl)-1H-Indole-3-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated benzyl-indole structure. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new therapeutic agents, particularly in oncology and CNS drug discovery.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its reactive aldehyde and halogenated aromatic groups.
• Agrochemical Research: Serves as a precursor in the synthesis of novel pesticides and herbicides, leveraging its halogenated indole scaffold.
• Chemical Biology Probe Development: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific target molecules.
• Academic Research: Used in university and institutional labs for fundamental organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	1-(2-Chloro-4-Fluorobenzyl)-1H-Indole-3-Carbaldehyde
CAS No.	525570-33-6
Molecular Formula	C16H11ClFNO
Molecular Weight	287.72 g/mol
Synonyms	1-[(2-Chloro-4-fluorophenyl)methyl]-1H-indole-3-carboxaldehyde; 1H-Indole-3-carboxaldehyde, 1-[(2-chloro-4-fluorophenyl)methyl]-; 3-Formyl-1-(2-chloro-4-fluorobenzyl)indole; 1-(2-Chloro-4-fluorobenzyl)indole-3-carboxaldehyde; 525570-33-6; 1-(2-Chloro-4-fluorobenzyl)-1H-indole-3-carbaldehyde; 1-(2-Chloro-4-fluorobenzyl)indole-3-carbaldehyde
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-4-Fluorobenzyl)-1H-Indole-3-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and rigorous in-process controls guarantees a reliable supply of this high-value intermediate for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.