Description

Pyrrolo[2,1-A]Isoquinolin-3(2H)-One, 1,5,6,10B-Tetrahydro-1,2-Dihydroxy-, (1R,2R,10Bs)- (9Ci) is a high-purity, stereochemically defined organic compound that serves as a critical chiral building block in advanced pharmaceutical synthesis. Its unique fused polycyclic structure with multiple functional groups makes it a valuable intermediate for developing novel active pharmaceutical ingredients (APIs) with specific biological activity. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of complex small-molecule therapeutics, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or intermediate in stereoselective organic synthesis to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes due to its rigid, polycyclic scaffold.
• Process Chemistry Development: Serves as a reference standard or an intermediate in scaling up synthetic routes from laboratory to pilot plant scale.
• Academic Research: Used in university and institutional labs for methodological development in organic chemistry and catalysis.
• Contract Research & Manufacturing (CRMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	Pyrrolo[2,1-A]Isoquinolin-3(2H)-One, 1,5,6,10B-Tetrahydro-1,2-Dihydroxy-, (1R,2R,10Bs)- (9Ci)
CAS No.	524950-94-5
Molecular Formula	C12H13NO3
Molecular Weight	219.24 g/mol
Synonyms	(1R,2R,10bS)-1,2-Dihydroxy-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one; (1R,2R,10bS)-1,2,5,6,10,10b-Hexahydro-3H-pyrrolo[2,1-a]isoquinoline-1,2-diol-3-one; Pyrroloisoquinolinone diol derivative; (1R,2R,10bS)-Tetrahydro-1,2-dihydroxypyrrolo[2,1-a]isoquinolin-3(2H)-one; Chiral pyrroloisoquinoline scaffold
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, enantiomeric excess, and impurity profiles. We support compliance with cGMP guidelines for materials intended for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccant packs.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.