Description

Dextrorphan-D3 Tartrate is a deuterium-labeled analog of the NMDA receptor antagonist dextrorphan, where three hydrogen atoms are replaced by deuterium at specific positions. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in mass spectrometry-based analyses. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of dextrorphan and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Forensic and Clinical Toxicology: Used in confirmatory testing and monitoring for dextromethorphan abuse or overdose.
• Drug Metabolism Research (DMPK): Facilitates the identification and quantification of metabolite formation and clearance pathways.
• Method Development and Validation: Serves as a critical reference material for developing robust, regulatory-compliant analytical assays (e.g., following FDA/EMA guidelines).
• Quality Control in Reference Material Production: Acts as a calibrant for certifying the purity and concentration of unlabeled dextrorphan standards.

Basic Information

Product Name	Dextrorphan-D3 Tartrate
CAS No.	524713-59-5
Molecular Formula	C17H20D3NO•C4H6O6
Molecular Weight	~ 414.45 g/mol
Synonyms	(+)-17-Methyl-9α,13α,14α-morphinan-3-ol-d3 Tartrate; Dextrorphan-d3 Tartrate Salt; 3-Hydroxy-N-methylmorphinan-d3 Tartrate; (9α,13α,14α)-3-Hydroxy-17-methylmorphinan-d3 Tartrate; Dextrorphan (phenyl-d3) Tartrate; Dextrorphan-D3 Hydrogen Tartrate; d3-Dextrorphan Tartrate; Internal Standard for Dextrorphan
EINECS	Contact for details

Quality Control

Our Dextrorphan-D3 Tartrate is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (≥98 atom % D), and chemical purity (typically ≥95%). Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.