Description

3,6,9,12,15-Pentaoxahexadecane-1-Thiol CAS NO 524030-00-0 is a specialized polyethylene glycol (PEG) derivative featuring a terminal thiol (-SH) functional group. This compound is highly valued for its role as a heterobifunctional linker, enabling the conjugation of biomolecules, polymers, and surfaces through thiol-reactive chemistries such as maleimide or iodoacetyl coupling. It is essential for researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science who require precise and stable cross-linking agents.

Application

• Bioconjugation and Protein Modification: Used as a linker to attach peptides, antibodies, or other proteins to surfaces, nanoparticles, or drug molecules.
• PEGylation Reagent: Serves as a key intermediate for creating PEGylated therapeutics to improve drug solubility, stability, and circulation time.
• Surface Functionalization: Enables the creation of self-assembled monolayers (SAMs) on gold or other metal surfaces for biosensor and diagnostic device development.
• Polymer Chemistry: Acts as a chain transfer agent (CTA) or functional initiator in controlled radical polymerization (e.g., RAFT) to synthesize telechelic polymers.
• Hydrogel Formation: Utilized in cross-linking networks to create biocompatible hydrogels for tissue engineering and drug delivery systems.
• Nanoparticle Capping Agent: Provides a stabilizing and functional coating for quantum dots, metallic nanoparticles, and liposomes.

Basic Information

Product Name	3,6,9,12,15-Pentaoxahexadecane-1-Thiol
CAS No.	524030-00-0
Molecular Formula	C11H24O5S
Molecular Weight	268.37 g/mol
Synonyms	HS-PEG5-OH; α-Thiol-ω-hydroxy pentaethylene glycol; 16-Mercapto-3,6,9,12,15-pentaoxahexadecan-1-ol; Mercapto-PEG5-alcohol; 1-Mercapto-3,6,9,12,15-pentaoxahexadecane; Thiol-PEG5-OH; PEG5-thiol; 2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol
EINECS	Contact for details

Quality Control

Our 3,6,9,12,15-Pentaoxahexadecane-1-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for thiol content, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group. For long-term storage, desiccate to protect against moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Thiol Content (Titration)	≥ 90%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.