Description

1-(4-Chloromethyl-Thiazol-2-Yl)-Piperidine is a high-value heterocyclic building block featuring a piperidine ring linked to a functionalized thiazole core. This compound is critical for pharmaceutical research and development, serving as a versatile intermediate in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of potential drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable chloromethyl and piperidine groups.
• Agrochemical Synthesis: Serves as a building block for creating novel pesticides and herbicides with specific biological activity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	1-(4-Chloromethyl-Thiazol-2-Yl)-Piperidine
CAS No.	521267-10-7
Molecular Formula	C9H13ClN2S
Molecular Weight	216.73 g/mol
Synonyms	2-(4-Chloromethyl-1,3-thiazol-2-yl)piperidine; 1-(4-Chloromethyl-1,3-thiazol-2-yl)piperidine; 2-Piperidin-1-yl-4-chloromethyl-thiazole; 4-(Chloromethyl)-2-(1-piperidinyl)-1,3-thiazole; 4-(Chloromethyl)-2-piperidin-1-yl-1,3-thiazole; Piperidine, 1-(4-chloromethyl-2-thiazolyl)-; 1-(4-Chloromethyl-thiazol-2-yl)-piperidine
EINECS	Contact for details

Quality Control

Our 1-(4-Chloromethyl-Thiazol-2-Yl)-Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports applications in GMP-aligned development and ensures reliable performance in critical synthetic steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.