Description

1H-Indole-1-Carboxylic Acid, 5-[(4-Methyl-1-Piperazinyl)Sulfonyl]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or oncology.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the exploration of new pharmacophores containing indole and sulfonamide moieties.
• API Synthesis: Employed in the production route for potential APIs where the 5-[(4-methyl-1-piperazinyl)sulfonyl] substitution is essential for biological activity.
• Chemical Biology Probes: Can be utilized in the development of specialized probes and tool compounds for biochemical and pharmacological research.
• Custom Synthesis: A starting material for contract manufacturing and custom synthesis projects requiring high-purity, bespoke organic molecules.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 5-[(4-Methyl-1-Piperazinyl)Sulfonyl]-, 1,1-Dimethylethyl Ester
CAS No.	519148-73-3
Molecular Formula	C19H27N3O4S
Molecular Weight	393.50 g/mol
Synonyms	tert-Butyl 5-[(4-methylpiperazin-1-yl)sulfonyl]-1H-indole-1-carboxylate; 5-[(4-Methyl-1-piperazinyl)sulfonyl]-1H-indole-1-carboxylic Acid 1,1-Dimethylethyl Ester; 1-(tert-Butoxycarbonyl)-5-[(4-methylpiperazin-1-yl)sulfonyl]indole; 1-Boc-5-[(4-methylpiperazin-1-yl)sulfonyl]indole; 5-(N-Methylpiperazinylsulfonyl)-1H-indole-1-carboxylic Acid tert-Butyl Ester; CAS 519148-73-3
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Carboxylic Acid, 5-[(4-Methyl-1-Piperazinyl)Sulfonyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.