Description

8-tert-Butyl-3-Fluoro-2-Hydroxyquinoline is a high-purity, functionalized quinoline derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and valuable building block for the development of novel pharmaceuticals, agrochemicals, and specialty materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of new-generation pesticides, herbicides, and fungicides, leveraging the biological activity of the quinoline scaffold.
• Ligand Synthesis: Acts as a starting material for creating complex chelating ligands used in catalysis and material science.
• Fluorescent Probe Development: The fluorinated hydroxyquinoline structure is utilized in the design of sensors and imaging agents for biochemical research.
• Material Science: Employed in the synthesis of organic electronic materials and metal-organic frameworks (MOFs) due to its rigid, functionalized structure.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects.

Basic Information

Product Name	8-tert-Butyl-3-Fluoro-2-Hydroxyquinoline
CAS No.	518070-27-4
Molecular Formula	C₁₃H₁₄FNO
Molecular Weight	219.26 g/mol
Synonyms	8-(tert-Butyl)-3-fluoro-2-hydroxyquinoline; 3-Fluoro-8-tert-butylquinolin-2-ol; 2-Hydroxy-8-tert-butyl-3-fluoroquinoline; 8-tert-Butyl-3-fluoroquinolin-2-ol; 518070-27-4; 3-Fluoro-8-(1,1-dimethylethyl)-2-quinolinol; 2-Quinolinol, 3-fluoro-8-(1,1-dimethylethyl)-
EINECS	Contact for details

Quality Control

Our 8-tert-Butyl-3-Fluoro-2-Hydroxyquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.