Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is a high-value nitrogen-containing heterocyclic building block, specifically a fused pyrrolopyridine derivative. This compound is of significant interest for its role as a key synthetic intermediate in modern pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry, particularly for the synthesis of novel kinase inhibitors and other biologically active molecules. The nitrile group offers a versatile handle for further functionalization, enabling the construction of complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and develop novel drug candidates.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Potential use as a monomer or precursor for constructing organic electronic materials, such as ligands in OLEDs or conductive polymers.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile
CAS No.	517918-95-5
Molecular Formula	C8H5N3
Molecular Weight	143.15 g/mol
Synonyms	5-Cyano-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile; 5-Cyanopyrrolo[2,3-b]pyridine; 7-Azaindole-5-carbonitrile; 5-Cyano-7-azaindole; Pyrrolo[2,3-b]pyridine-5-carbonitrile; 5-CN-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports your research and development needs with reliable, high-purity building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.