Description

1H-Indole, 1-(Chloroacetyl)-2,3-Dihydro-2-Methyl-, (2R)- (9Ci) is a high-purity, chiral indole derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block, offering a unique stereochemical handle and reactive chloroacetyl group for constructing complex molecular architectures. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by specialty chemical manufacturers producing fine chemicals and catalysts.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and other biologically active molecules.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the indole scaffold and specific stereochemistry are crucial for bioactivity.
• Asymmetric Catalysis Ligand Synthesis: Serves as a starting material for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for research and industrial applications.
• Academic & Institutional Research: Utilized in chemical biology and medicinal chemistry programs to study structure-activity relationships and develop new synthetic methodologies.

Basic Information

Item	Details
Product Name	1H-Indole, 1-(Chloroacetyl)-2,3-Dihydro-2-Methyl-, (2R)- (9Ci)
CAS No.	517866-45-4
Molecular Formula	C11H12ClNO2
Molecular Weight	225.67 g/mol
Synonyms	(2R)-1-(Chloroacetyl)-2-methyl-2,3-dihydro-1H-indole; (R)-1-(Chloroacetyl)-2-methylindoline; 1-(Chloroacetyl)-2-methylindoline, (R)-; 2,3-Dihydro-2-methyl-1H-indol-1-yl-chloroethanone, (2R)-; (R)-N-(Chloroacetyl)-2-methylindoline; 517866-45-4; (R)-1-Chloroacetyl-2-methylindoline
EINECS	Contact for details

Quality Control

Our production of 1H-Indole, 1-(Chloroacetyl)-2,3-Dihydro-2-Methyl-, (2R)- (9Ci) adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure consistent identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.