Description

1-Azabicyclo[2.2.2]Octane,3-Ethynyl-3-Methoxy-,(3R)-(9Ci) is a chiral, nitrogen-containing bicyclic building block featuring an ethynyl and methoxy substituent. This compound matters as a sophisticated intermediate for the synthesis of complex molecules, particularly in pharmaceutical research where its rigid scaffold and functional handles are highly valuable. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical research and development applications.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and receptor-targeted therapies.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies due to its unique, constrained 3D geometry.
• Ligand and Catalyst Development: Serves as a precursor for creating novel nitrogen-based ligands for asymmetric catalysis.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents with specific stereochemical requirements.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Academic Research: Employed in universities and research institutes for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-Azabicyclo[2.2.2]Octane,3-Ethynyl-3-Methoxy-,(3R)-(9Ci)
CAS No.	515154-59-3
Molecular Formula	C10H15NO
Molecular Weight	165.23 g/mol
Synonyms	(3R)-3-Ethynyl-3-methoxy-1-azabicyclo[2.2.2]octane; 3-Ethynyl-3-methoxyquinuclidine; (R)-3-Ethynyl-3-methoxyquinuclidine; 1-Azabicyclo[2.2.2]octane, 3-ethynyl-3-methoxy-, (3R)-; Quinuclidine, 3-ethynyl-3-methoxy-, (3R)-; 515154-59-3; (R)-3-Methoxy-3-(ethynyl)quinuclidine
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[2.2.2]Octane,3-Ethynyl-3-Methoxy-,(3R)-(9Ci) is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.