Description

2H-Pyrrol-2-One, 4-Acetyl-1-(4-Bromophenyl)-5-Cyclohexyl-1,5-Dihydro-3-Hydroxy- is a high-purity, advanced pharmaceutical intermediate characterized by its complex pyrrolone core structure. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. Pharmaceutical R&D departments and fine chemical manufacturers need this material for developing next-generation therapeutic candidates, where its specific bromophenyl and cyclohexyl substituents are essential for achieving desired biological activity and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, especially in neurological and anti-inflammatory research pipelines.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial material.
• Academic Research: Employed in university and institutional labs for investigating new heterocyclic compounds and their biochemical interactions.
• High-Value Fine Chemical Production: Serves as a starting material for synthesizing other specialized pyrrolone derivatives with commercial potential.

Basic Information

Item	Detail
Product Name	2H-Pyrrol-2-One, 4-Acetyl-1-(4-Bromophenyl)-5-Cyclohexyl-1,5-Dihydro-3-Hydroxy-
CAS No.	512176-59-9
Molecular Formula	C18H20BrNO3
Molecular Weight	378.26 g/mol
Synonyms	4-Acetyl-1-(4-bromophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one; 1-(4-Bromophenyl)-5-cyclohexyl-4-acetyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one; 4-Acetyl-1-(4-bromophenyl)-5-cyclohexyl-3-hydroxy-2-pyrrolone; CAS 512176-59-9; Bromophenyl Cyclohexyl Dihydroxypyrrolone Derivative; Advanced Pyrrolone Intermediate
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced under strict quality management systems to ensure identity, purity, and consistency. Our rigorous quality testing includes multiple orthogonal analytical methods to verify compliance with client specifications and internal standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, impurity profiles, and results from tests such as HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.