Description

((2-Bromo-5-Methoxybenzyl)Oxy)(tert-Butyl)Dimethylsilane is a high-purity organosilicon reagent featuring a bromo-methoxybenzyl protecting group. This compound is a critical synthetic intermediate valued for its role in constructing complex molecules, particularly in pharmaceutical research and fine chemical synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the protection of alcohols and the introduction of functionalized aromatic moieties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring protected hydroxyl groups or specific bromo-aromatic substitutions.
• Peptide & Nucleotide Chemistry: Used as a protecting group reagent for hydroxyl functions during the solid-phase and solution-phase synthesis of complex biomolecules.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators that incorporate methoxybenzyl motifs.
• Material Science Research: Serves as a precursor or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, to form biaryl structures.
• Academic & Contract Research: Essential reagent for methodological development and exploratory synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	((2-Bromo-5-Methoxybenzyl)Oxy)(tert-Butyl)Dimethylsilane
CAS No.	511277-90-0
Molecular Formula	C₁₄H₂₃BrO₂Si
Molecular Weight	331.33 g/mol
Synonyms	tert-Butyl((2-bromo-5-methoxybenzyl)oxy)dimethylsilane; (2-Bromo-5-methoxybenzyloxy)-tert-butyldimethylsilane; TBDMS Ether of 2-Bromo-5-methoxybenzyl alcohol; 1-((tert-Butyldimethylsilyl)oxy)methyl-2-bromo-5-methoxybenzene; 2-Bromo-5-methoxybenzyl tert-butyldimethylsilyl ether; 2-Br-5-MeO-Bn-OTBDMS; (2-Br-5-MeO-C₆H₃-CH₂-O-SiMe₂-tBu)
EINECS	Contact for details

Quality Control

Our production of ((2-Bromo-5-Methoxybenzyl)Oxy)(tert-Butyl)Dimethylsilane adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.