Description

Diphenyl[3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Propyl]Phosphine Oxide is a specialized organophosphorus compound featuring a tetrahydropyran-protected hydroxypropyl linker, making it a valuable building block in advanced synthetic chemistry. This compound is crucial for its role as a ligand precursor or intermediate in the development of pharmaceuticals, agrochemicals, and functional materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, fine chemical, and catalyst manufacturing industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring phosphine oxide functionalities.
• Ligand Synthesis: Acts as a precursor for chiral or bidentate phosphine ligands used in asymmetric catalysis, such as cross-coupling and hydrogenation reactions.
• Agrochemical Research: Utilized in the development of novel herbicides, fungicides, and plant growth regulators where the phosphine oxide group modulates biological activity.
• Material Science: Employed in the creation of flame retardants, polymer modifiers, and specialty additives due to its thermally stable phosphine oxide core.
• Organic Synthesis Building Block: The protected hydroxyl group allows for selective functionalization, making it useful in multi-step synthetic routes for complex organic molecules.
• Coordination Chemistry: Used to prepare metal complexes for catalytic applications or as models for studying metal-ligand interactions.

Basic Information

Product Name	Diphenyl[3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Propyl]Phosphine Oxide
CAS No.	503817-58-1
Molecular Formula	C20H25O2P
Molecular Weight	328.39 g/mol
Synonyms	(3-((Tetrahydro-2H-pyran-2-yl)oxy)propyl)diphenylphosphine oxide; 2-[3-(Diphenylphosphinyl)propoxy]tetrahydropyran; Diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)phosphine oxide; THP-protected hydroxypropyl diphenylphosphine oxide; 503817-58-1; Diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)phosphine oxide
EINECS	Contact for details

Quality Control

Our Diphenyl[3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Propyl]Phosphine Oxide undergoes rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. We employ advanced analytical techniques including HPLC, NMR, and GC to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.