Description

5-Iodo-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected indole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic placement of the iodine atom and the acid-labile tert-butyl ester protecting group, enabling selective functionalization and complex molecule assembly. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with complex indole-based structures.
• Material Science Research: Serves as a precursor for functional organic materials, including organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse biaryl and alkynyl compounds.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	5-Iodo-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	503614-74-2
Molecular Formula	C13H16INO2
Molecular Weight	345.18 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 5-iodo-2,3-dihydro-, 1,1-dimethylethyl ester; tert-Butyl 5-iodo-2,3-dihydro-1H-indole-1-carboxylate; 5-Iodoindoline-1-carboxylic acid tert-butyl ester; Boc-5-Iodoindoline; N-Boc-5-iodoindoline; 5-Iodo-N-Boc-indoline; 503614-74-2
EINECS	Contact for details

Quality Control

Our 5-Iodo-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process chemistry. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to guarantee reliable supply and traceability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.