Description

3-Pyridinemethanol, 5-Ethyl-4-(4-Fluoro-2-Hydroxyphenyl)-A-Methyl-2,6-Bis(1-Methylethyl)-, (Ar,4R)- (9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) requiring specific chiral configurations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel, high-potency Active Pharmaceutical Ingredients (APIs).
• Chiral Synthesis: Serves as a critical precursor in asymmetric synthesis for creating enantiomerically pure drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot and commercial production scales.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	3-Pyridinemethanol, 5-Ethyl-4-(4-Fluoro-2-Hydroxyphenyl)-A-Methyl-2,6-Bis(1-Methylethyl)-, (Ar,4R)- (9Ci)
CAS No.	503610-16-0
Molecular Formula	C22H30FNO2
Molecular Weight	359.48 g/mol
Synonyms	(4R)-5-Ethyl-4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-bis(1-methylethyl)-3-pyridinemethanol; (Ar,4R)-5-Ethyl-4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-diisopropyl-3-pyridinemethanol; 5-Ethyl-4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-diisopropyl-3-pyridinemethanol (Ar,4R)-; CAS 503610-16-0; 3-Pyridinemethanol derivative (chiral); Diisopropylpyridinemethanol intermediate; Fluorohydroxyphenyl pyridinemethanol
EINECS	Contact for details

Quality Control

Our 3-Pyridinemethanol, 5-Ethyl-4-(4-Fluoro-2-Hydroxyphenyl)-A-Methyl-2,6-Bis(1-Methylethyl)-, (Ar,4R)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.