Description

3-Pyridinemethanol, 5-Butyl-4-(4-Fluoro-2-Hydroxyphenyl)-A-Methyl-2,6-Bis(1-Methylethyl)-, (Ar,4S)- (9Ci) is a high-purity, chiral synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a pyridinemethanol core with multiple stereocenters and substituents, makes it a valuable building block for constructing novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors working on new therapeutic agents, particularly in areas requiring sophisticated chiral synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel, complex drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development stages for creating new APIs with specific stereochemical requirements.
• Asymmetric Synthesis: Employed as a key substrate or reagent in catalytic asymmetric reactions to introduce chirality into target molecules.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Chemical Biology Probes: Potential use in the development of chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	3-Pyridinemethanol, 5-Butyl-4-(4-Fluoro-2-Hydroxyphenyl)-A-Methyl-2,6-Bis(1-Methylethyl)-, (Ar,4S)- (9Ci)
CAS No.	503610-08-0
Molecular Formula	C24H34FNO2
Molecular Weight	387.53 g/mol
Synonyms	(4S)-5-Butyl-4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-bis(1-methylethyl)-3-pyridinemethanol; 5-Butyl-4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-diisopropyl-3-pyridinemethanol, (αR,4S)-; (αR,4S)-5-Butyl-4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-di(propan-2-yl)pyridine-3-methanol; CAS 503610-08-0; (Ar,4S)-5-Butyl-4-(4-fluoro-2-hydroxyphenyl)-A-Methyl-2,6-Bis(1-methylethyl)-3-Pyridinemethanol; 3-Pyridinemethanol, 5-butyl-4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-bis(1-methylethyl)-, (αR,4S)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for pharmaceutical R&D. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, chiral purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.