Description

2,3(1H)-Isoquinolinedicarboxylic Acid, Octahydro-6-Hydroxy-, 2-Methyl Ester, (3S,4As,6S,8Ar)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. It is primarily needed by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly in central nervous system (CNS) and cardiovascular research.
• Organic Synthesis Building Block: Used in multi-step synthetic routes to construct fused polycyclic frameworks common in medicinal chemistry.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development of new stereoselective synthetic methodologies.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Institutional Research: Utilized in university and research institute laboratories for exploring new chemical entities and biological activity.
• Process Development & Scale-Up: Critical for optimizing synthetic routes from milligram to kilogram scale in pre-clinical and clinical API manufacturing.

Basic Information

Product Name	2,3(1H)-Isoquinolinedicarboxylic Acid, Octahydro-6-Hydroxy-, 2-Methyl Ester, (3S,4As,6S,8Ar)-
CAS No.	503293-98-9
Molecular Formula	C13H19NO5
Molecular Weight	269.29 g/mol
Synonyms	(3S,4aS,6S,8aR)-Octahydro-6-hydroxy-2-methyl 2,3(1H)-isoquinolinedicarboxylate; (3S,4aS,6S,8aR)-Octahydro-6-hydroxy-2-methyl ester-2,3(1H)-isoquinolinedicarboxylic acid; 2-Methyl (3S,4aS,6S,8aR)-octahydro-6-hydroxy-1H-2,3-isoquinolinedicarboxylate; Octahydro-6-hydroxy-2,3(1H)-isoquinolinedicarboxylic acid 2-methyl ester (3S,4aS,6S,8aR)-; 503293-98-9; (3S,4aS,6S,8aR)-rel-Octahydro-6-hydroxy-2-methyl 2,3(1H)-isoquinolinedicarboxylate
EINECS	Contact for details

Quality Control

Our 2,3(1H)-Isoquinolinedicarboxylic Acid, Octahydro-6-Hydroxy-, 2-Methyl Ester, (3S,4As,6S,8Ar)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development. COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.