Description

1H-Indole-1-Carboxylic Acid, 5-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Sulfonyl]-, 1,1-Dimethylethyl Ester is a high-purity, synthetically valuable chemical intermediate featuring a complex indole-piperazine sulfonamide structure. This compound matters for its role as a critical building block in the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research. Pharmaceutical R&D teams and fine chemical manufacturers need it for synthesizing potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes within drug discovery programs.
• Protease Inhibitor Development: The sulfonamide and indole motifs make it a valuable scaffold for designing enzyme inhibitors.
• Bioconjugation & Chemical Probe Synthesis: Utilized in creating labeled compounds or probes for biochemical and pharmacological assays.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical companies offering bespoke synthesis services to the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis and heterocyclic chemistry studies.

Basic Information

Item	Details
Product Name	1H-Indole-1-Carboxylic Acid, 5-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Sulfonyl]-, 1,1-Dimethylethyl Ester
CAS No.	503045-76-9
Molecular Formula	C24H35N3O6S
Molecular Weight	493.62 g/mol
Synonyms	tert-Butyl 5-[(4-(tert-butoxycarbonyl)piperazin-1-yl)sulfonyl]-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-[(4-(tert-butoxycarbonyl)piperazin-1-yl)sulfonyl]indole; 5-[(4-(Boc)piperazin-1-yl)sulfonyl]-1-(Boc)indole; 1-Boc-5-[(4-Boc-piperazin-1-yl)sulfonyl]indole; 1H-Indole-1-carboxylic acid, 5-[[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]sulfonyl]-, 1,1-dimethylethyl ester; Boc-Protected Indole-Piperazine Sulfonamide; tert-Butyl 5-(4-(tert-butoxycarbonyl)piperazine-1-sulfonyl)-1H-indole-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Carboxylic Acid, 5-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Sulfonyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.