Description

2-Hydroxyphenylboronic Acid Thp-Ether is a specialized, high-value boronic acid derivative where the phenolic hydroxyl group is protected as a tetrahydropyranyl (THP) ether. This compound is a critical building block in modern synthetic organic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions, where it offers enhanced stability and solubility compared to its unprotected counterpart. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient synthesis of complex biaryl structures and functionalized molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific biaryl motifs.
• Material Science: Building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel bidentate ligands and organoboron catalysts.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors due to its reactive boronic acid moiety.
• Academic and Industrial R&D: Essential reagent for method development and exploring new synthetic pathways in laboratory settings.

Basic Information

Product Name	2-Hydroxyphenylboronic Acid Thp-Ether
CAS No.	502159-01-5
Molecular Formula	C₁₁H₁₅BO₃
Molecular Weight	206.05 g/mol
Synonyms	2-(Tetrahydro-2H-pyran-2-yloxy)phenylboronic Acid; 2-(THP-O)C₆H₄B(OH)₂; [2-(Tetrahydro-2-pyranyloxy)phenyl]boronic Acid; Boronic acid, B-[2-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-; 2-(Tetrahydro-2H-pyran-2-yloxy)benzeneboronic Acid; THP-Protected 2-Hydroxyphenylboronic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxyphenylboronic Acid Thp-Ether is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.