Description

Cycloprop[A]Indene-1-Carboxylic Acid, 4-Cyano-1,1A,6,6A-Tetrahydro-, (1R,1As,6Ar)-Rel- (9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its complex, fused-ring structure which serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and process R&D for therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique cyclopropane-fused indene scaffold.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Exploited for its defined stereochemistry in the construction of complex, enantiomerically pure molecules.
• Contract Research & Manufacturing (CRMO): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	Cycloprop[A]Indene-1-Carboxylic Acid, 4-Cyano-1,1A,6,6A-Tetrahydro-, (1R,1As,6Ar)-Rel- (9Ci)
CAS No.	501373-10-0
Molecular Formula	C13H11NO2
Molecular Weight	213.23 g/mol
Synonyms	rel-(1R,1aS,6aR)-4-Cyano-1,1a,6,6a-tetrahydrocyclopropa[a]indene-1-carboxylic acid; (1R,1aS,6aR)-4-Cyano-1,1a,6,6a-tetrahydrocyclopropa[a]indene-1-carboxylic acid; 4-Cyano-1,1a,6,6a-tetrahydrocyclopropa[a]indene-1-carboxylic acid; Cyclopropa[a]indene-1-carboxylic acid, 4-cyano-1,1a,6,6a-tetrahydro-, (1R,1aS,6aR)-rel-; CAS 501373-10-0; Advanced Pharmaceutical Intermediate 501373-10-0; Chiral Cyclopropane-Fused Indene Derivative.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced and controlled under a strict quality management system. Certificates of Analysis (COA) are provided with each batch, detailing key parameters such as chiral purity, chemical purity, and identity confirmation. Our quality protocols are designed to support regulatory filings, ensuring reliable and consistent material for critical research and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.