Description

2-Thiophenecarboxamide,5-(Aminomethyl)-n-(1S,2R,4R)-7- is a high-purity, chiral organic compound featuring a thiophene core with an amide and an aminomethyl functional group. This specific stereochemistry makes it a critical building block in the synthesis of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where precise molecular structure is paramount for efficacy and safety.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drug candidates.
• Organic Synthesis Building Block: Used in advanced multi-step organic synthesis to construct complex heterocyclic frameworks due to its reactive amide and primary amine groups.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and high-throughput screening in drug discovery programs.
• Asymmetric Catalysis Studies: Employed as a ligand precursor or a substrate in the development of new asymmetric synthetic methodologies.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	2-Thiophenecarboxamide,5-(Aminomethyl)-n-(1S,2R,4R)-7-
CAS No.	500605-49-2
Molecular Formula	C7H10N2OS
Molecular Weight	170.23 g/mol
Synonyms	5-(Aminomethyl)-N-[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]thiophene-2-carboxamide; (1S,2R,4R)-N-[5-(Aminomethyl)-2-thienyl]-7-oxabicyclo[2.2.1]heptane-2-carboxamide; 5-(Aminomethyl)-N-(7-oxabicyclo[2.2.1]hept-2-yl)thiophene-2-carboxamide; Bicyclo[2.2.1]heptane-2-carboxamide, 5-(aminomethyl)-N-(7-oxa-, (1S,2R,4R)-; Thiophene-2-carboxamide derivative (S,R,R isomer); A key intermediate for pharmaceutical synthesis.
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is controlled via modern analytical techniques to guarantee identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.