Description

6α-Chloro-4,5α-Epoxy-17-Methylmorphinan-3-Ol is a high-purity synthetic opioid intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a critical precursor for the synthesis of specialized analgesic compounds and for pharmacological studies. This compound is essential for R&D laboratories and manufacturing facilities focused on developing new therapeutic agents within the central nervous system (CNS) space. CAS No. 59971-06-1.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent opioid analgesics and related therapeutic molecules.
• Analgesic Research: Used in preclinical and pharmacological research to study structure-activity relationships (SAR) of morphinan derivatives.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical analysis.
• Medicinal Chemistry: Employed in medicinal chemistry programs for the design and development of novel compounds targeting opioid receptors.
• Process Development: Utilized in the development and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	6α-Chloro-4,5α-Epoxy-17-Methylmorphinan-3-Ol
CAS No.	59971-06-1
Molecular Formula	C₁₈H₂₂ClNO₂
Molecular Weight	319.83 g/mol
Synonyms	6α-Chloro-17-methyl-4,5α-epoxymorphinan-3-ol; 6α-Chloronaltrexone; 6α-Chloro-4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan; 6α-Chloro-17-methylmorphinan-3-ol, 4,5-epoxy-; 6α-Chloro-17-methyl-4,5α-epoxy-3-hydroxymorphinan; Naltrexone 6α-chloro derivative
EINECS	Contact for details

Quality Control

Our 6α-Chloro-4,5α-Epoxy-17-Methylmorphinan-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.