Description

(S)-2,3,10,11A-Tetrahydro-1H-Benzo[E]Pyrrolo[1,2-A][1,4]Diazepin-11(5H)-One is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex heterocyclic molecules and drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of proprietary drug candidates and active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial laboratories for constructing complex benzodiazepine and pyrrolo-diazepine scaffolds.
• Asymmetric Catalysis Studies: Serves as a substrate or ligand precursor in the development of new chiral catalysts and synthetic methodologies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the discovery of new bioactive molecules targeting the central nervous system and other therapeutic areas.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-2,3,10,11A-Tetrahydro-1H-Benzo[E]Pyrrolo[1,2-A][1,4]Diazepin-11(5H)-One
CAS No.	59824-68-9
Molecular Formula	C₁₄H₁₆N₂O
Molecular Weight	228.29 g/mol
Synonyms	(S)-Tetrahydrobenzo[e]pyrrolo[1,2-a][1,4]diazepin-11(5H)-one; (S)-5,6,7,8-Tetrahydro-1H-pyrrolo[1,2-a][1,4]benzodiazepin-11(10H)-one; (S)-Benzopyrrolodiazepinone; (S)-THBP; (S)-Enantiomer of Pyrrolobenzodiazepine precursor; (5S)-2,3,10,11a-Tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-11(5H)-one
EINECS	Contact for details

Quality Control

Our production of (S)-2,3,10,11A-Tetrahydro-1H-Benzo[E]Pyrrolo[1,2-A][1,4]Diazepin-11(5H)-One adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity. All materials are characterized by advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with cGMP, ICH guidelines, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.