Description

2H-1,3,2-Oxazaphosphorin-5-D-2-Amine, N,n-Bis(2-Chloroethyl)Tetrahydro -5-D-, 2-Oxide is a specialized, isotopically labeled derivative of a key nitrogen mustard phosphoramide compound. This product is critical for advanced research and development, particularly in mechanistic studies and analytical method development where deuterium labeling provides essential tracking capabilities. It is primarily sought by pharmaceutical researchers, contract research organizations (CROs), and academic institutions engaged in oncology drug discovery and metabolism studies.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quality control and quantification of active pharmaceutical ingredients (APIs) and related substances.
• Metabolic Pathway Tracing: The deuterium label enables precise tracking of drug metabolism and biotransformation pathways in preclinical and clinical research.
• Mass Spectrometry Internal Standard: Used as a stable isotope-labeled internal standard (SIL-IS) in LC-MS/MS and GC-MS analyses for accurate and reliable bioanalytical assays.
• Mechanistic Biochemical Research: Facilitates studies on the mechanism of action of alkylating agents at the molecular level.
• Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradation products in complex chemical matrices.

Basic Information

Product Name	2H-1,3,2-Oxazaphosphorin-5-D-2-Amine, N,n-Bis(2-Chloroethyl)Tetrahydro -5-D-, 2-Oxide
CAS No.	59720-09-1
Molecular Formula	C7H14DCl2N2O2P
Molecular Weight	Contact for details
Synonyms	Cyclophosphamide-d4 (major metabolite)
4-Hydroxycyclophosphamide-d4
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine-5,5,6,6-d4 2-oxide
Deuterated Aldophosphamide
2H-1,3,2-Oxazaphosphorinane, 2-[bis(2-chloroethyl)amino]tetrahydro-5,5,6,6-d4- 2-oxide
Stable Isotope Labeled Cyclophosphamide Metabolite
Perdeuterated 4-Hydroxycyclophosphamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity reference materials. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment, and chemical purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 90%
Water Content	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.