Description

Bezitramide Hydrochloride is a potent synthetic opioid analgesic compound. It is primarily valued in pharmaceutical research and development for its high-affinity binding to opioid receptors, making it a critical reference standard and intermediate. This compound is essential for researchers and manufacturers in the pharmaceutical industry focusing on neuropharmacology, pain management, and the development of controlled analgesic substances. Its precise chemical profile is crucial for ensuring the accuracy and reliability of analytical methods and pharmacological studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for quality control and analytical method development in drug testing laboratories.
• Pharmacological Research: Serves as a key tool in neuroscience and pain research for studying opioid receptor mechanisms and signal transduction pathways.
• Analytical Chemistry: Employed as a calibration standard in advanced chromatographic (HPLC, GC-MS) and spectroscopic analyses for forensic and clinical toxicology.
• Drug Development Intermediate: Acts as a critical synthetic intermediate or precursor in the research phase for novel analgesic compounds.
• Biochemical Assays: Utilized in in vitro binding assays and enzyme studies to evaluate the potency and selectivity of new chemical entities.
• Controlled Substance Analysis: Essential for regulatory and forensic agencies in the identification and quantification of opioids in compliance with international drug control schedules.

Basic Information

Product Name	Bezitramide Hydrochloride
CAS No.	59708-44-0
Molecular Formula	C₂₈H₃₂N₂O₂·HCl
Molecular Weight	481.03 g/mol
Synonyms	Burgodin Hydrochloride; R 4845 Hydrochloride; 1-(3-Cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)piperidine Hydrochloride; NIH 10466; 1-(3-Cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine Hydrochloride; Bezitramid Hydrochloride
EINECS	Contact for details

Quality Control

Our Bezitramide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities, to ensure it meets the stringent requirements for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications tailored for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.