Description

(4-(Trifluoromethyl)-1H-Imidazol-5-Yl)Methanol is a versatile trifluoromethyl-substituted imidazole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the imidazole heterocycle and the electron-withdrawing trifluoromethyl group, which is essential for modulating the physicochemical properties of target molecules. This high-purity intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the CF3 group enhances bioavailability and metabolic stability.
• Ligand & Catalyst Development: Used in the preparation of specialized N-heterocyclic ligands for metal-catalyzed cross-coupling reactions.
• Material Science Research: Precursor for functionalized ionic liquids or organic frameworks with tailored electronic properties.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) in fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D pipelines.

Basic Information

Product Name	(4-(Trifluoromethyl)-1H-Imidazol-5-Yl)Methanol
CAS No.	59608-85-4
Molecular Formula	C5H5F3N2O
Molecular Weight	166.10 g/mol
Synonyms	5-(Hydroxymethyl)-4-(trifluoromethyl)-1H-imidazole; 4-(Trifluoromethyl)-1H-imidazole-5-methanol; 1H-Imidazole-5-methanol, 4-(trifluoromethyl)-; (4-Trifluoromethyl-1H-imidazol-5-yl)methanol; 5-Hydroxymethyl-4-trifluoromethylimidazole; α-(Trifluoromethyl)-1H-imidazole-5-methanol
EINECS	Contact for details

Quality Control

Our (4-(Trifluoromethyl)-1H-Imidazol-5-Yl)Methanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.