Description

2-Bromo-6-Fluoro-Benzenethiol is a versatile organosulfur building block characterized by its reactive thiol (-SH) group and halogen substituents. This compound matters as a critical intermediate for constructing complex molecules in advanced pharmaceutical and agrochemical research, enabling the introduction of sulfur and halogen functionalities. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in drug discovery, ligand synthesis, and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, leveraging its halogenated aromatic structure.
• Ligand and Catalyst Preparation: Serves as a precursor for metal-chelating ligands in catalysis and as a modifier for catalytic surfaces.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create thiol-reactive probes and bioconjugation reagents for protein labeling and study.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to form carbon-sulfur bonds.

Basic Information

Item	Details
Product Name	2-Bromo-6-Fluoro-Benzenethiol
CAS No.	59594-64-8
Molecular Formula	C6H4BrFS
Molecular Weight	207.06 g/mol
Synonyms	2-Bromo-6-fluorobenzenethiol; 2-Bromo-6-fluorothiophenol; 1-Bromo-3-fluoro-2-mercaptobenzene; 2-Fluoro-6-bromobenzenethiol; Benzenethiol, 2-bromo-6-fluoro-; (2-Bromo-6-fluorophenyl)thiol; 2-Bromo-6-fluorophenyl mercaptan
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Fluoro-Benzenethiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.