Description

1H-Benzimidazole,2-(2-Pyrrolidinyl)-,(S)-(9Ci) is a chiral benzimidazole derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and high-value pharmaceutical intermediate and chiral building block for the development of active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel therapeutic agents, particularly those targeting neurological and cardiovascular systems.
• Asymmetric Synthesis: Employed as a chiral ligand or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Fine Chemical Production: Building block for the manufacture of complex, high-value specialty chemicals and advanced materials.

Basic Information

Product Name	1H-Benzimidazole,2-(2-Pyrrolidinyl)-,(S)-(9Ci)
CAS No.	59592-35-7
Molecular Formula	C11H13N3
Molecular Weight	187.24 g/mol
Synonyms	(S)-2-(2-Pyrrolidinyl)-1H-benzimidazole; (S)-2-(Pyrrolidin-2-yl)-1H-benzo[d]imidazole; (S)-2-(2-Pyrrolidinyl)benzimidazole; (S)-α-(2-Pyrrolidinyl)-1H-benzimidazole; (S)-PBI; (S)-2-(1-Pyrrolidinyl)benzimidazole (common misnomer); (S)-2-Pyrrolidin-2-yl-1H-benzoimidazole; L-2-(2-Pyrrolidinyl)benzimidazole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purity levels suitable for research and commercial synthesis. Certificates of Analysis (COA) are available upon request, detailing parameters such as chiral purity, chemical purity, and residual solvent content. Our quality systems support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥98.0% ee
Loss on Drying	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.