Description

(3-Bromopropoxy)-tert-Butyldimethylsilane is a versatile organosilicon reagent featuring a bromopropyl group protected by a tert-butyldimethylsilyl (TBDMS) ether. This compound matters as a key synthetic building block, enabling the controlled introduction of a functionalized three-carbon linker into complex molecules. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs), ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthon for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring a bromoalkyl ether linkage.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where the protected bromopropoxy moiety is incorporated into the final active molecule.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized phosphine or nitrogen-based ligands used in asymmetric catalysis and transition metal complexes.
• Polymer & Material Science: Employed in the synthesis of functionalized siloxane polymers, surface-modifying agents, and advanced organic-inorganic hybrid materials.
• Organic Synthesis Building Block: Provides a protected, nucleophile-sensitive handle for carbon-chain elongation and the construction of complex ether and thioether derivatives in multi-step syntheses.
• Protecting Group Strategy: The TBDMS group offers stability under various reaction conditions, allowing selective deprotection of the bromo function for further derivatization.

Basic Information

Product Name	(3-Bromopropoxy)-tert-Butyldimethylsilane
CAS No.	59501-41-6
Molecular Formula	C9H21BrOSi
Molecular Weight	253.26 g/mol
Synonyms	3-Bromopropoxy-tert-butyldimethylsilane; tert-Butyl(3-bromopropoxy)dimethylsilane; 1-[(tert-Butyldimethylsilyl)oxy]-3-bromopropane; 3-Bromo-1-((tert-butyldimethylsilyl)oxy)propane; (3-Bromopropoxy)(tert-butyl)dimethylsilane; TBDMS 3-Bromopropyl Ether; 3-Bromopropyl tert-butyldimethylsilyl ether; Silane, (3-bromopropoxy)-1,1-dimethylethyl)dimethyl-
EINECS	Contact for details

Quality Control

Our (3-Bromopropoxy)-tert-Butyldimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its moisture-sensitive nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.