Description

trans-3-(Trimethylsilyl)Allyl Alcohol is a versatile organosilicon compound featuring both a reactive allylic alcohol group and a trimethylsilyl (TMS) protecting group. This dual functionality makes it a valuable synthetic building block and intermediate in advanced organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing protected hydroxyl and silicon-containing moieties.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides, leveraging its reactivity for carbon-chain elongation.
• Organosilicon Chemistry: Serves as a precursor for other functionalized silanes and silicone derivatives used in materials science.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Heck, Stille, or Suzuki couplings for C-C bond formation.
• Asymmetric Synthesis: Employed in the preparation of chiral compounds, where the TMS group can act as a stereocontrolling element or temporary protector.
• Polymer Modification: Used to incorporate silicon functionalities into polymer backbones to alter properties like thermal stability, hydrophobicity, or adhesion.
• Material Science Research: Investigated for developing novel organic-inorganic hybrid materials and surface modifiers.

Basic Information

Product Name	trans-3-(Trimethylsilyl)Allyl Alcohol
CAS No.	59376-64-6
Molecular Formula	C6H14OSi
Molecular Weight	130.26 g/mol
Synonyms	3-Trimethylsilyl-2-propen-1-ol; (E)-3-(Trimethylsilyl)allyl alcohol; 2-Propen-1-ol, 3-(trimethylsilyl)-, (2E)-; (E)-3-(Trimethylsilyl)prop-2-en-1-ol; TMS-allyl alcohol; trans-3-(Trimethylsilyl)-2-propen-1-ol; Allyl alcohol, 3-(trimethylsilyl)-, (E)-
EINECS	Contact for details

Quality Control

Our trans-3-(Trimethylsilyl)Allyl Alcohol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets precise specifications for research and industrial use. Certificates of Analysis (COA) detailing purity, isomer content, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Isomeric Purity (trans-isomer)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.