Description

2-Bromotetrahydrofuran is a versatile halogenated cyclic ether, widely recognized as a key building block in organic synthesis. Its primary value lies in its reactivity as an alkylating agent and its utility as a protected form of 4-bromobutanol, enabling the construction of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to introduce tetrahydrofuran or bromoalkyl moieties into target molecules.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing heterocyclic cores and side chains.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and other crop protection agents that require brominated ether functionalities.
• Polymer Chemistry: Serves as a monomer or modifier in the synthesis of specialty polymers and resins, influencing material properties.
• Organic Synthesis Building Block: Employed in nucleophilic substitution reactions, Grignard reagent formation, and as a precursor to other functionalized tetrahydrofurans.
• Ligand and Catalyst Preparation: Useful in the preparation of specialized ligands for metal-catalyzed cross-coupling and other transition metal-mediated reactions.
• Material Science Research: Investigated for its properties in liquid crystals, electrolytes, and other advanced material applications.

Basic Information

Product Name	2-Bromotetrahydrofuran
CAS No.	59253-21-3
Molecular Formula	C4H7BrO
Molecular Weight	151.00 g/mol
Synonyms	2-Bromooxolane; α-Bromotetrahydrofuran; Tetrahydro-2-bromofuran; 2-Bromo-tetrahydrofuran; 2-Bromo-oxacyclopentane; THF-2-bromide; 2-Br-THF; Bromofuran, tetrahydro-
EINECS	Contact for details

Quality Control

Our 2-Bromotetrahydrofuran is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including purity by GC or HPLC, identity confirmation by IR and NMR, and control of key impurities and water content. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP or ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (at 20°C)	~1.50 g/mL
Refractive Index (n20/D)	~1.48

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.